It depends on what the octane ratings of the grades you use, which vary from state to state in the US. A rating of 87 is "regular" in most places, and the owner's manual for the 124 Spider cautions against using fuel with ratings below 87, declaring that this could damage the engine. There may be places where 85 octane is "regular." I hadn't heard before that switching between grades was bad for the engine, unless you switched to a lower (87) octane where pre-ignition knock might intrude. In that case, the engine would be "adjusting" more during one tankful than in making a switch to a higher grade. But I'm no expert.